![]() Goorley T, McKinney G, Adams K, Estes G: MCNP enhancements, parallel computing, and error analysis for BNCT, In: Hawthorne MF, Shelly K, Wiersema RJ (eds) Frontiers in Neutron Capture Therapy, Vol 1, Kluwer Academic/Plenum Publishers, New York, 2001 Zamenhof RG, Redmond EL, Solares G, Katz D, Riley K, Kiger S, Harling O: Monte Carlo based treatment planning for boron neutron capture therapy using custom designed models automatically generated from CT Data, Int J Rad Oncol Biol Phys 35: 383–397, 1996 Ingersol DT, Slater CO, Redmond EL, Zamenhof RG: Comparison of TORT and MCNP Dose Calculations for BNCT Treatment Planning', In: Larsson B, Crawford J, Weinreich (eds) Advances in Neutron Capture Therapy, Vol I, Medicine and Physics, Elsevier Science BV, 1997 Moran JM, Nigg DW, Wheeler FJ, Bauer WF: Macroscopic geometric heterogeneity effects in radiation dose distribution analysis for boron neutron capture therapy. Nigg DW, Randolph PD, Wheeler FJ: Demonstration of three-dimensional deterministic radiation transport theory dose distribution analysis for boron neutron capture therapy. Version 4A, LA-12625–M, Los Alamos National Laboratory, USA, 1993 Med Phys 27: 359–367, 2000īriesmeister JF: MCNP - a general Monte Carlo N-particle transport code. Nigg DW, Wemple CA, Risler R, Hartwell JK, Harker YD, Laramore GE: Modification of the University of Washington neutron radiotherapy facility for optimization of neutron capture enhanced fast-neutron therapy. Laramore GE, Wootton P, Livesey JC, Wilbur DS, Risler R, Phillips M, Jacky J, Bucholtz TA, Griffin TW, Brossard S: Boron neutron capture therapy - a mechanism for achieving a concomitant tumor boost in fast neutron radiotherapy. Nakagawa Y, Hatanaka H: Boron neutron capture therapy - clinical brain tumor studies. Yanch JC, Shortkoff S, Sheffer RE, Johnson S, Binello E, Gierga D, Jones AG, Young G, Viveros C, Davison A, Sledge C: Boron neutron capture synovestomy - treatment of rheumatoid arthritis based on the 10B( n, α) 7 Li reaction. Sweet WH: The use of nuclear disintegrations in the diagnosis and treatment of brain tumors. Locher GL: Biological effects and therapeutic possibilities of neutrons. Various institutions have their own procedures, but standard validation models are not yet in wide use. Validation and benchmarking of computations for NCT are also of current developmental interest. A key issue with NCT treatment planning has to do with boron quantification, and whether improved information concerning the spatial biodistribution of boron can be effectively used to improve the treatment planning process. Most recently, interest has turned toward the creation of treatment planning software that is not limited to any specific therapy modality, with NCT as only one of several applications. However, historically, there has also been interest in the application of deterministic methods, and there have been some practical developments in this area. Treatment planning systems that have been successfully introduced for NCT applications over the past 15 years rely on the Monte Carlo stochastic simulation method for the necessary computations, primarily because of the geometric complexity of human anatomy. One generally must obtain an explicit three-dimensional numerical solution of the governing transport equation, with energy-dependent neutron scattering completely taken into account. The standard simplifying approximations that work well for treatment planning computations in the case of many other modalities are usually not appropriate for application to neutron transport. Specialized treatment planning software systems are generally required for neutron capture therapy (NCT) research and clinical applications.
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